Overview Oral Presentation Sessions

OP-01 // Ototoxicity I

Chairs: S. Sha, Charleston, SC, USA; A. Martini, Padua, Italy

(1) J. Ogier, Parkville, Australia
Inhibition of Apoptotic Signal Regulating Kinase 1 (ASK1): A potential strategy for the prevention of acquired hearing loss

(2) M. Cortada, Basel, Switzerland
Telmisartan protects auditory hair cells from in vitro-induced toxicity of gentamicin

(3) Y.-J. Hwang, Seoul, Republic of Korea
Verification of therapeutic and adverse effect of Biogel for intratympanic drug delivery

(4) E. Gentilin, Padua, Italy
Prevention of cisplatin ototoxicity by dexamethasone and nanoceria in an inner ear cell line

(5) S. Levano, Basel, Switzerland
Mechanism of cisplatin-induced ototoxicity: Implication of Sesn2/AMPK pathway

(6) A. Monge Naldi, Zürich, Switzerland
Neuronal erythropoietin overexpression is protective against kanamycin induced hearing loss in mice

OP-02 // Inner ear development

Chairs: P. Wangemann, USA; H. Schulze, Erlangen, Germany

Role of endocytosis in neurotrophin-mediated neuritogenesis and survival of spiral ganglion neurons (1) A.F. Ryan, La Jolla, CA, USA

(2) L. Rüttiger, Tübingen, Germany
Gi proteins are indispensable for hearing

(3) P. Jean, Göttingen, Germany
A role for Gai and planar polarity in the position-dependent regulation of synapse properties in inner hair cells

OP-03 // Vestibular system

Chairs: J.A. Lopez Escamez, Granada, Spain; S.H. Kim, Seoul, Republic of Korea

(1) J. Llorens, L´Hospitalet de Llob, Spain
Quantitative assessment of the tail-lift reflex to measure vestibular dysfunction in rats

(2) M. Flook Pereira, Granada, Spain
Pro-inflammatory cytokines and gene expression profile in peripheral blood mononuclear cells in patients with Vestibular Migraine and Meniere's Disease

(3) J.A. Lopez Escamez, Granada, Spain
Enrichment of rare missense variants in sensorineural hearing loss genes in the genome of patients with sporadic Meniere disease

(4) S.H. Kim, Seoul, Republic of Korea
Supra-gravity stimulation deteriorates vestibular function in the mouse with selective P2RX2 deficit

(5) T.-S. Noh, Seoul, Republic of Korea
Quantitative 3D volume measurement of endolymphatic hydrops has a good correlation with the severity and history of vertigo in Meniere's Disease

OP-04 // Ototoxicity II

Chairs: S. Vlajkovic, Auckland, New Zealand; J. Schacht, Ann Arbor, USA

(1) S. Vlajkovic, Auckland, New Zealand
Regulators of G protein signalling as novel targets for the treatment of sensorineural hearing loss

(2) Y.-H. Choung, Suwon, Republic of Korea
Activation of cAMP in cochlear supporting cells indirectly prevents hair cell survival via gap junctional intercellular communication

(3) S. Sha, Charleston, SC, USA
Epigenetic modification of histones in acquired hearing loss

(4) K. Rajput, London, United Kingdom
Sodium Thiosulfate as otoprotectant to reduce Cisplatin induced hearing loss in children with liver cancer

(5) K. Kucharava, Basel, Switzerland
Somatostatin analog - Pasireotide: A novel treatment for the protection of cochlear hair cells In Vivo

(6) P. Gjorstrup, Cambridge, MA, USA
AP-(1)/NPD1 pleiotropic actions on multiple targets confer protection from cisplatin-induced hearing loss

OP-05 // Technical approaches for functional restauration

Chairs: P. Santi, Minneapolis, USA; S. Safieddine, Paris, France

(1) M. Sato, Osakasayama, Japan
Manipulation of hearing loss by optogenetic approach to nonexcitable nonglial cells in the inner ear

(2) T. Nakagawa, Kyoto, Japan
Implantation of a piezoelectric device into guinea pig cochleae damaged by aminoglycoside

(3) D. Dulon, Bordeaux, France
Viral transfer of mini-otoferlins restores the fast component of exocytosis and uncovers ultrafast endocytosis in auditory hair cells of otoferlin knock-out mice

OP-06 // Stem cell

Chairs: M. Rivolta, United Kingdom; A.F. Ryan, La Jolla, CA, USA

(1) L. Straatman, Utrecht, The Netherlands
Magnetic stem cell targeting to the inner ear

(2) L. Abbas, Sheffield, United Kingdom
Defining the immunological properties of hESC-derived otic neural progenitors in the context of the gerbil auditory neuropathy model

(3) H. Avci, Tübingen, Germany
Isolation, characterization and comparison of stem/progenitor cells in the human postmortem adult inner ear

OP-07 // Auditory processing

Chairs: M. Gröschel, Berlin, Germany; J. Wang, Halifax, Canada

(1) M. Gröschel, Berlin, Germany
Acute noise injury-associated intrinsic apoptosis in the central auditory pathway

(2) J. Wang, Halifax, Canada
Noise-induced cochlear synaptopathy and signal processing disorders

(3) M. Manthey, Tübingen, Germany
Influence of peripheral BDNF on maturation of the central auditory pathway

(4) D. Möhrle, Tübingen, Germany
GC-B deficient mice with axon bifurcation loss show compromised precision of auditory processing

(5) A. Herranen, Helsinki, Finland
How to deal with environmental stressors? A role for the cochlear non-sensory cells

(6) A.R. Fetoni, Rome, Italy
Cochlear deafferentation induced by noise exposure causes structural plasticity changes in the auditory cortex

OP-08 // Circadian rhythms and emotional stress

Chairs: B. Canlon, Stockholm, Sweden; B. Mazurek, Berlin, Germany

(1) J.M. Park, Seoul, Republic of Korea
Association between stress and tinnitus in a dual stress rat model

(2) P. Eckert, Tübingen, Germany
Visualizing transcript-specific BDNF expression during sound-induced memory linked plasticity changes

(3) E. Tserga, Stockholm, Sweden
Circadian vulnerability to cisplatin in GLAST deficient mice

(4) J.M. Fontana, Solna, Sweden
Circadian regulation of sensitivity to noise trauma in different mouse strains

OP-09 // Pharmacological interventions: IGF

Chairs: I. Varela Nieto, Madrid, Spain; T. Nakagawa, Kyoto, Japan

(1) N. Yamamoto, Kyoto, Japan
Hearing preservation at low frequencies by insulin-like growth factor 1 in a guinea pig model of cochlear implantation

(2) D. Skerleva, Kyoto, Japan
Topical IGF-1 treatment against age-related hearing loss in mice

OP-10 // Aging

Chairs: S. Dazert, Bochum, Germany; H. Staecker, Kansas City, USA

(1) S. Dazert, Bochum, Germany
Cochlear implantation changes neurocognition in elderly patients

(2) F. Rousset, Geneva, Switzerland
Loss of function mutation in the NADPH oxidase subunit p22phox prevents early onset hearing loss

OP-11 // Regeneration and protection

Chairs: H. Löwenheim, Tübingen, Germany; H. Versnel, Utrecht, The Netherlands

(1) F. Piu, San Diego, CA, USA
Development of OTO-413 an intratympanic sustained-exposure formulation of the neurotrophic factor BDNF for the treatment of cochlear synaptopathy

(2) H. Versnel, Utrecht, The Netherlands
Responsiveness of the auditory nerve compared between BDNF and NT-3 treatment

(3) H. Staecker, Kansas City, USA
Analysis of neurotrophin signaling in the human inner ear using miRNA profiling

(4) M. Fujioka, Tokyo, Japan
Topical administration of a gamma-secretase inhibitor LY411575 into the round window niche ameliorates permanent threshold shift in a noise-induced hearing loss model of a non-human primate, the common marmoset

OP-12 // Functional and cellular aspects of the cochlear and vestibular systems

Chairs: C. Harasztosi, Tübingen, Germany; S. Masetto, Pavia, Italy

(1) J.-H. Nam, Rochester, USA
Outer hair cell motility can suppress organ of Corti vibrations

(2) C. Harasztosi, Tübingen, Germany
Endocytic activity and vesicle traffic in outer hair cells

(3) M. Magarinos, Madrid, Spain
Cellular senescence contributes to morphogenesis and differentiation during the early development of the chicken inner ear: implication of transforming growth factor beta 2

(4) F. Sanjust, Monte Porzio Catone, Italy
Intensimetric approach provides a new tool to detect distortion product otoacoustic emissions with ear canal calibration

(5) P. Santi, Minneapolis, USA
Imaging of the Cochlea with light-sheet microscopy

(6) S. Masetto, Pavia, Italy
Non conventional signal transmission at the mouse vestibular Type I hair cell - calyx synapse

(7) P. Perin, Pavia, Italy
Choroid plexus association to the auditory system: observations in a clarified brainstem-inner ear preparation

OP-13 // Tinnitus

Chairs: M. Knipper, Tübingen, Germany; P. van Dijk, Groningen, The Netherlands

(1) B. Hofmeier, Tübingen, Germany
Reduced sound-evoked and resting-state BOLD fMRI connectivity in tinnitus

(2) K. Kiyomizu, Nobeoka, Miyazaki, Japan
Psychiatric comorbidity in patients with tinnitus or auditory hallucination

OP-14 // Cochlear implantation

Chairs: D. Basta, Berlin, Germany; N. Peter-Siegrist, Zurich, Switzerland

(1) U. Reich, Berlin, Germany
Development of novel electrical stimulation device for tinnitus suppression via inner ear - a technical study

(2) D. Basta, Berlin, Germany
Reduced hair cell loss after cochlear implantation following pre-treatment by near-infrared-light

(3) A. Warnecke, Hannover, Germany
Dose-dependent reduction of impedances after steroid application via a cochlear catheter in human cochlear implantation

(4) S. Strieth, Mainz, Germany
In vivo-analysis of the cochlear lateral wall for hearing preserving cochlear implantations

(5) N. Peter-Siegrist, Zurich, Switzerland
Cochlear-implantation in single sided deafness: influence of the laterality on audiological and clinical results

(6) N. Ahmadi, Wien, Austria
Dexamethasone-eluting cochlear implant electrodes in combination with glucocorticoid-loaded hydrogels: effects on hearing preservation and impedances

OP-15 // Clinical aspects of hearing

Chairs: A. Warnecke, Hannover, Germany; A. Ernst, Germany

(1) D. Nunez, Vancouver, BC, Canada
Are there detectable changes in the circulating microRNAs profile of sudden sensorineural sufferers?

(2) M. Pylypiuk, Ivano-Frankivsk, Ukraine
Types of hearing loss analysis among partients examined at the Hearing Centre in Ivano-Frankivsk, Ukraine

(3) A. Nagy, Szeged, Hungary
Investigations on the genetic background of nonsyndromic hereditary hearing loss in Hungarian patients

(4) S. Schwartz, Lublin, Poland
Impact of otitis media with effusion on the vestibular system in children

(5) V. Szuts, Szeged, Hungary
Expression of connexins and Kir2.1 ion channel proteins altered in hearing loss patients before cochlear implantation

(6) M. Meyer, Zürich, Switzerland
On the relationship between tinnitus, hearing loss, and impaired speech perception